This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.   Thank you to our sponsors: <ul> <li>Athletic Greens - <a href= "http://www.athleticgreens.com/huberman">http://www.athleticgreens.com/huberman</a></li> <li>Belcampo - <a href= "http://www.belcampo.com/huberman">http://www.belcampo.com/huberman</a></li> <li>InsideTracker - <a href= "http://www.insidetracker.com/huberman">http://www.insidetracker.com/huberman</a></li> </ul>   Dr. Matthew Johnson Social Media:  <ul> <li>Twitter: <a href= "https://twitter.com/drug_researcher">https://twitter.com/drug_researcher</a> </li> <li>Instagram: <a href= "https://instagram.com/drug_researcher">https://instagram.com/drug_researcher</a> </li> </ul>   Our Patreon page: <ul> <li><a href= "https://www.patreon.com/andrewhuberman">https://www.patreon.com/andrewhuberman</a> </li> </ul>   Supplements from Thorne: <ul> <li><a href= "http://www.thorne.com/u/huberman">http://www.thorne.com/u/huberman</a> </li> </ul>   Social: <ul> <li>Instagram - <a href= "https://www.instagram.com/hubermanlab">https://www.instagram.com/hubermanlab</a> </li> <li>Twitter - <a href= "https://twitter.com/hubermanlab">https://twitter.com/hubermanlab</a> </li> <li>Facebook - <a href= "https://www.facebook.com/hubermanlab">https://www.facebook.com/hubermanlab</a> </li> <li>Website - <a href= "https://hubermanlab.com">https://hubermanlab.com</a> </li> <li>Newsletter - <a href= "https://hubermanlab.com/neural-network">https://hubermanlab.com/neural-network</a> </li> </ul>   Links: <ul> <li>Dr. Johnson’s Website at Johns Hopkins School of Medicine - <a href= "https://hopkinspsychedelic.org/johnson">https://hopkinspsychedelic.org/johnson</a></li> <li>Chris Letheby’s forthcoming book - <a href= "https://amzn.to/3nMTaAs">https://amzn.to/3nMTaAs</a>  </li> </ul>   Timestamps: <ul> <li>00:00:00 Introducing Dr. Matthew Johnson</li> <li>00:02:10 Supporting Sponsors</li> <li>00:06:40 ‘Psychedelics’ Defined</li> <li>00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception</li> <li>00:19:56 Serotonin & Dopamine </li> <li>00:23:50 Ketamine & Glutamate </li> <li>00:28:00 An Example Psychedelic Experiment</li> <li>00:37:30 ‘Letting Go’ with Psychedelics</li> <li>00:44:10 Our Mind’s Eye</li> <li>00:48:00 Redefining Your Sense of Self </li> <li>00:58:56 Exporting Psychedelic Learnings to Daily Life</li> <li>01:04:36 Flashbacks</li> <li>01:12:10 Ayahuasca, & ASMR, Kundalini Breathing</li> <li>01:15:54 MDMA, DMT</li> <li>01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis</li> <li>01:38:15 Micro-Dosing</li> <li>01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials</li> <li>02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation</li> <li>02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury </li> <li>02:27:45 Shifting Trends in Psychedelic Research, Academic Culture</li> <li>02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork </li> <li>02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements </li> </ul> Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

Dr. Matthew Johnson: Psychedelic Medicine | Episode 38

Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.